Prevalence of mixed neuropathologies in autopsied older adults and associations
  
   Lead Investigator:    Willa Brenowitz
   Institution      :     
   E-Mail           :    lmbesser@uw.edu
   Proposal ID      :    511


   Publications:


1  Brenowitz WD,  Hubbard RA, Hawes SE, Keene CD, Longstreth WT, Crane PK, Larson EB,  Kukull WA
   Comorbid brain conditions in older adults with clinical Alzheimer's disease
   2017   Abstract  Am J Epidemiol , 

   ACCEPTED



2  Brenowitz WD , Hubbard RA, Keene CD, Hawes SE, Longstreth T, Woltjer RL,  Kukull WA
   Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample
   Journal Article  Alzheimers Dement,6:654-662,2017,PMC5438283

   PUBLISHED



3  Brenowitz WD , Hubbard RA, Keene D, Hawes SE, Longstreth WT, Jr.,  Kukull WA
   Clinical progression in mixed neuropathologies: testing interactions of Lewy bodies and vascular brain injury with Alzheimer's disease neuropathologic change
   Abstract  Alzheimers Dement,12:P736-P737,2016,

   PUBLISHED



4  Brenowitz WD , Hubbard RA, Keene D, Hawes SE, Longstreth WT, Jr., Woltjer RL,  Kukull WA
   Mixed neuropathologies and associations with domain-specific cognitive decline
   Journal Article  Neurology,89:1773-1781,2017,PMC5664309

   PUBLISHED



5  Brenowitz WD , Keene CD, Hawes SE, Hubbard RA, Longstreth Jr WT, Woltjer RL, Crane PK, Larson EB,  Kukull WA
   Alzheimer's disease neuropathologic change, Lewy body disease, and vascular brain injury in clinic- and community-based samples
   Journal Article  Neurobiol Aging,53:83-92,2017,PMC5385292

   PUBLISHED





   Proposal Description:
   The goal of this research is to characterize and investigate the clinical importance of multiple co-occurring pathologies (aka mixed neuropathologies) capable of causing dementia. We propose to use previously collected autopsy and clinical data from NACC on older adults (with any level of cognitive impairment prior to death) to address the following Specific Aims:                                                                                                             1. To estimate and compare prevalence of mixed and single neuropathologies        (focusing on AD pathology, microinfarcts, and Lewy bodies) between a clinic and population based study.                                                             1.1. To describe clinical and pathologic characteristics of individuals with mixed, single, and low AD, microinfarct, and Lewy body neuropathologies.                                                                                            2. To evaluate whether mixed neuropathologies are associated with worse           severity and faster progression of a.) overall clinical impairment and b.)        impairment in specific cognitive domains, compared to those with single and low AD, microinfarct, and Lewy body neuropathologies.                                   2.1.  To evaluate whether Lewy bodies or cerebrovascular pathology (specifically microinfarcts) statistically interact with AD pathology to associate with clinical symptoms.